Download
Abstract
Sleep is critical for consolidating all forms of memory, from episodic experience to the development of motor skills. A core feature of the consolidation process is offline replay of neuronal firing patterns that occur during experience. This replay is thought to originate in the hippocampus and trigger the reactivation of ensembles of cortical and subcortical neurons. However, non-declarative memories do not require the hippocampus for learning or for sleep-dependent consolidation meaning what drives their consolidation is unknown. Here we show, using an unsupervised method, that replay occurs in the dorsal striatum of mice during offline consolidation of a non-declarative, procedural, memory and that this replay is generated independently of the hippocampus. Replay occurred at both real-world and time-compressed speeds and was also prioritised both at the level of the individual neurons and the type of neural sequence. Complete bilateral lesions of the hippocampus had no effect on any feature of this replay. Our results demonstrate that procedural replay during consolidation of a non-declarative memory is independent of the hippocampus. These results support the view that replay drives active consolidation of all types of memory during sleep but challenges the idea that the hippocampus is the source of this replay.
Citation
Thompson, E., Rollik, L., Waked, B., Mills, G., Kaur, J., Geva, B., Carrasco-Davis, R., George, T., Domine, C., Dorrell, W. and Stephenson-Jones, M., 2024. Replay of procedural experience is independent of the hippocampus. bioRxiv, pp.2024-06.
@article{thompson2024replay,
title={Replay of procedural experience is independent of the hippocampus},
author={Thompson, Emmett and Rollik, Lars and Waked, Benjamin and Mills, Georgina and Kaur, Jasvin and Geva, Ben and Carrasco-Davis, Rodrigo and George, Tom and Domine, Clementine and Dorrell, William and others},
journal={bioRxiv},
pages={2024--06},
year={2024},
publisher={Cold Spring Harbor Laboratory}
}